Can there be mitosis without DNA replication in S phase?

Solution:
Mitotic cell division cannot take place without DNA replication in S phase. Two important events take place during S phase – one is the synthesis or duplication of DNA and the other is the duplication of the centriole. DNA duplication is important as it maintains the chromosome number in the daughter cells. Mitosis is an equational division. Therefore, the duplication of DNA is an important step.